Paris, France (Sports Network) - Six-time champion Rafael Nadal and three- time Grand Slam runner-up Andy Murray, bothered by a back injury on Thursday, were a pair of second-round winners at the French Open.

The second-seeded former world No. 1 Nadal dropped only four games in a 6-2, 6-2, 6-0 plastering of Uzbekistan's Denis Istomin on Court Lenglen. Nadal dropped only five games in his opening-round win this week.

Nadal is now 47-1 lifetime on the red clay at Roland Garros, including his Open-Era-record-tying six titles. He's currently the reigning two-time champ, including a victory over Roger Federer in last year's finale.

The 10-time major champion Nadal lost to Novak Djokovic in the last three Grand Slam finals.

The fourth-seeded Murray, meanwhile, received treatment for a bad back in a 1-6, 6-4, 6-1, 6-2 victory over Finnish veteran Jarkko Nieminen on Court Chatrier.

Murray, who lost to the great Nadal in his first-ever French Open semifinal here a year ago, has now reached the third round in Paris five straight years.

Up next for the British star will be Colombian Santiago Giraldo, who took out 25th-seeded Aussie Bernard Tomic 6-4, 6-1, 6-3.

Fifth-seeded French favorite Jo-Wilfried Tsonga completed a 6-2, 4-6, 6-2, 6-1 victory over German Cedrik-Marcel Stebe after their match was suspended because of rain here on Wednesday, while sixth-seeded Spaniard David Ferrer whipped Frenchman Benoit Paire 6-3, 6-3, 6-2 to secure a spot in the round of 32 for an eighth consecutive year.

Thirteenth-seeded Argentine Juan Monaco moved on by handling Czech Lukas Rosol 7-6 (7-4), 6-0, 7-6 (7-5).

In other second-round action involving seeds, No. 19 Canadian slugger Milos Raonic dismissed American Jesse Levine 6-4, 7-5, 6-2 and No. 27 Russian Mikhail Youzhny topped Dutchman Robin Haase 6-3, 7-6 (7-5), 6-4. Raonic will meet Monaco in his next outing, while Youzhny will face Ferrer in the next round.

Veteran French crowd favorite Arnaud Clement lost to Belgian David Goffin 3-6, 7-6 (7-2), 0-6, 6-2, 6-1 in a match that was suspended because of rain Wednesday with Goffin leading 5-1 in the fifth set.

05/31 10:19:14 ET